Product Introduction:
Cnidium may improve conditions including impotence, female
infertility, vaginal itching, and yeast infections. It often causes
a deterioration of symptoms in men with chronic spermatorrhea and
premature ejaculation. Cnidium has some astringent quality, which
means that it will help prevent premature ejaculation in men.
Furthermore, Cnidium seed has disinfectant qualities and may be
used externally as a wash on sores, particularly in the genital
region.
Coumarin compounds such as Osthole and Imperatorin as well as
Xanthotoxin (Methoxsalen). Isopimpinellin, and Bergapten have also
been identified Hydrated berries of Cnidii have concentrations
around 1.67-2.88% osthole.
Osthole is commonly seen as the primary active ingredient due to it
being the most prominent courmarin derivative in Cnidium
Monnieri,and is a coumarin derivative compound. It's true chemical
name is 7-methoxy-8{3-methylpent 2-enyl}coumarin.The fruits tend to
be used in Traditional Chinese Medicine, but the seeds of Cnidium
Monnieri contains these bioactives as well.
Product Description:
Product name | Cnidium Fruit Extract |
Plant source | Fructus Cnidii/ Cnidium monnieri |
Latin name | Fructus Cnidii |
Active Ingredients | Osthole |
Specifications: | Osthole 10% 35%,50% 80%90%95% 98% by HPLC,5:1, 10:1, 20:1 |
Test method | HPLC |
Molecular Formula: | C15H16O3 |
Molecular Weight: | 244.29 g/mol |
CAS No.: | 484-12-8 |
Appearance | Light yellow to white powder |
Standard | GMP,Kosher,HALAL,ISO9001. |
cnidium extract benefits
1. Skin Health
Cnidii Fructus (fruits of Cnidium) have traditionally been used
orally as an anti-allergic substance; when testing a variety of
traditional herbs (n=33 in total, 6 found to be effective) touted
to suppress skin irritation, Cnidium appears to be the most
effective in inhibiting substance-P induced itching behaviour in
mice.
Through the centuries, traditional Chinese medicine used cnidium to
treat skin conditions. Today, it is a popular ingredient in Chinese
skin creams, ointments and lotions.
The herb’s antibacterial, antifungal and antipruritic properties
make cnidium ideal for skin treatments. Holistic practitioners use
the extract for numerous skin conditions including dermatitis,
eczema, ringworm, rash and itching.
2. Men's Health
>Skeletal Muscle
Osthole has been implicated in increasing AMPK-mediated glucose
uptake into myocytes (both C2C12 and L6) in dose and time dependent
manners, although tested mostly at 12.5-50uM and also affects
hepatocytes to a less potent extent. Incubation of muscle cells
with 12.5uM and 50uM increases glucose uptake via GLUT4
translocation induced by AMPK by 1.6 and 2-fold; respectively.
These effects on AMPK may be due to shifting the AMP:ATP ratio, as
osthole seems to deplete ATP and elevate relative amounts of AMP,
which is known to be the lead inducer of skeletal muscle
AMPK.Osthole was known to be anti-glycemic in vivo at 50mg/kg prior
to the discovery of AMPK interactions, and was mimicked in
streptozotocin-induced diabetic mice at 100mg/kg osthole orally for
8 weeks.
Osthole apparently may also phosphorylate (activate) Akt, and the
downstream proteins of AS160 and GSK3; another mechanism by which
GLUT4 may be increased.
> Erections
Cnidium Monnieri is, supposedly, a frequently prescribed herb among
Chinese Medicine practitioners for male impotence. It has
traditionally been used for treatment of male erections (or the
lack thereof) alongside Epimedium Sagittatum (related to Horny Goat
Weed) and the plant Semen Cuscutae.
When examined in vitro on corpus cavernosum (penis wall) muscles,
the bioactive ingredient Osthole appears to be able to cause
muscular relaxation (pro-erectile) in a dose-dependent manner. The
mechanism may be via phosphodiesterase inhibition, as osthole
appears to potentiate cGMP induced relaxation as well as nitric
oxide. These effects are common to all coumarins in Cnidium
Monnieri, with Imperatorin being requiring the lowest concentration
to be effective.
There may also be central (brain) effects as well, due to the
ability of osthole to induce glutaminergic neurotransmission (see
Neurology section).
Not yet studied in humans, but has traditional usage of being an
erection promoting herb in Traditional Chinese Medicine and appears
to be active on both the penis tissues and the brain in similar
manners to Viagra.
3.Liver Interactions
>Fatty Liver
Osthole is able to reduce fatty liver induced by Alcohol; in a
study where mice were fed 52% of caloric intake as ethanol for 4
weeks and then given 10-40mg/kg Osthole for 6 weeks, Osthole was
able to normalize alterations in CPT1A and CYP2E1 transcription
rates (made abnormal with prolonged alcohol ingestion, and
conducive to further fat buildup) and was able to decrease liver
fat content in a rehabilitative manner.These effects are also seen
when the same dose of osthole is co-ingested, and are attributed to
anti-oxidant and anti-inflammatory mechansims, although Osthole
does appear to induce PPARa activation which can then reduce DGAT
and HMG-CoA activity; a shift towards lipid mobilization rather
than storage. Minor dose-dependence is seen, with more Osthole
exerting more protection but 10mg/kg seeming to be the most
cost-effective dose.
Other
Bodybuilders take cnidium supplements to increase energy and boost
athletic performance. Because it improves concentration and memory,
the herb is sometimes used to prevent Alzheimer’s disease and other
dementias. It is also beneficial for the weak, brittle bones of
osteoporosis.
Application:
1. Cnidium Fruit Extract Applied in pharmaceutical field, it is
usually made into tablets, capsule and granule to warm the kidney, strengthen the spleen and enhance human immunity.
2. Cnidium Fruit Extract Applied in food field, it is mainly used
in kinds of beverage, liquor and foods to enhance human immunity and anti-aging.
Package and shipping
Package: 25kg/drum (25kg net weight,28kg gross weight; Packed in a
cardboard-drum with two plastic-bags inside. Drum Size: 510mm high,
350mm diameter) ;
1kg/bag
Shipping: Shipping by Express mail (Fedex, DHL, TNT), Air and Sea.
We will deliver the order within 3-5 working days after receiving
your payment.