Local Anesthesia Powder Phenacetin / Benzocaine / Lidocaine
Manufacturer Pain Killers
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Product Name: Phenacetin
Product Categories: Amines;Aromatics;Other APIs;Intermediates &
Phenacetin Chemical Properties
Melting point 133-136 °C(lit.)
Boiling point 132 °C / 4mmHg
density 1.1248 (rough estimate)
refractive index 1.5710
storage temp. 2-8°C
pka pKa 2.2(H2O) (Uncertain);3.5(aqueous acetone) (Uncertain)
Water Solubility 0.076 g/100 mL
Stability: Stable. Incompatible with strong oxidizing agents,
Confirmed carcinogen producing tumors of the lildney and bladder. A
human poison by an unspecified route. Poison by intravenous and
possibly other routes. Moderately toxic by several routes. Human
systemic effects by ingestion: cyanosis, liver damage, and
methemoglobinemiacarboxyhemo-globinemia. Experimental teratogenic
data. Other experimental reproductive effects. Mutation data
reported. Chronic effects consist of weight loss, insomnia,
shortness of breath, weakness, and often aplastic anemia. When
heated to decomposition it emits toxic fumes of NOx,.
Phenacetin is used as an analgesic and antipyretic drug. It is used
alone or in combination with aspirin and caffeine for mild to
moderate muscle pain relief. Phenacetin has also been used as a
stabilizer for hydrogen peroxide in hair bleaching preparations. A
laboratory reagent. In veterinary medicine; it is used as an
analgesic and antipyretic.
Move victim to fresh air. Call 911 or emergency medical service.
Give artificial respiration if victim is not breathing. Do not use
mouth-to-mouth method if victim ingested or inhaled the substance;
give artificial respiration with the aid of a pocket mask equipped
with a one-way valve or other proper respiratory medical device.
Administer oxygen if breathing is difficult. Remove and isolate
contaminated clothing and shoes. In the case of contact with
substance, immediately flush skin or eyes with running water for at
least 20 minutes. For minor skin contact, avoid spreading material
on unaffected skin. Keep victim warm and quiet. Effects of exposure
(inhalation,ingestion or skin contact) to substance may be delayed.
Ensure that medical personnel are aware of the material(s) involved
and take precautions to protect themselves. Medical observation is
recommended for 24 to 48 hours after breathing overexposure, as
pulmonary edema may be delayed. As first aid for pulmonary edema, a
doctor or authorized paramedic may consider administering a drug or
other inhalation therapy.
Crystallise it from H2O or EtOH, and its solubility in H2O is 0.08%
(at ~10o) and 1.2% (at ~100o), and in EtOH it is 6.7% (at ~10o) and
36% (at ~100o). Alternatively it can be purified by solution in
cold dilute alkali and re-precipitating by addition of acid to
neutralisation point. Dry it in air. [Beilstein 13 H 461, 13 IV
Oxidizing agents, iodine and nitrating agents.
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